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Mag.pharm. Dr. Alexandra Maier-Salamon

e-mail

Phone: +43 1 4277 55573

Fax: +43 1 4277 9551

Room: 2E453


Teaching

321009 PR Nasschemische Arzneibuchanalytik

321109 PR Nasschemische Arzneibuchanalytik - Zusatzkurse

322020 PR PR Klinische Pharmazie und chemische Diagnostik


Publications

Journal Articles

  • Jäger W, Winter O, Halper B, Salamon A, Satori M, Gajdzik L, Hamilton G, Theyer G, Graf J, Thalhammer T: Modulation of liver canicular transport processes by the tyrosine kinase inhibitor genistein: implication of genistein metabolites in rats. Hepatology 26:1467-76. (1997)

  • Salamon A, Vielnascher E, Hagenauer B, Szekeres T, Szekeres-Fritzer M, Thalhammer T, Jager W. Metabolism of the new ribonucleotide reductase inhibitor amidox in the isolated perfused rat liver. Anticancer Res. 20(5B):3521-6. (2000)

  • Hamwi A, Salamon A, Steinbrugger R, Fritzer-Szekeres M, Jager W, Szekeres T. Cyclosporine metabolism in patients after kidney, bone marrow, heart-lung, and liver transplantation in the early and late posttransplant periods. Am J Clin Pathol.;114(4):536-43. (2000)

  • Hagenauer B, Salamon A, Thalhammer T, Kunert O, Haslinger E, Klingler P, Senderowicz AM, Sausville EA, Jager W. In vitro glucuronidation of the cyclin-dependent kinase inhibitor flavopiridol by rat and human liver microsomes: involvement of UDP-glucuronosyltransferases 1A1 and 1A9. Drug Metab Dispos.; 29(4 Pt 1):407-14. (2001)

  • Salamon A, Hagenauer B, Thalhammer T, Szekeres T, Krohn K, Jayaram HN, Jäger W. Metabolism and disposition of the novel antileukaemic drug, benzamide riboside, in the isolated perfused rat liver. Life Sci. 12;69(21):2489-502. (2001)

  • Jäger W., Salamon A., Szekeres T. Metabolism of the novel IMP Dehydrogenase inhibitor benzamide riboside. Curr Med Chem.; 9(7):781-6. (2002)  
  • Fritzer-Szekeres M, Salamon A, Grusch M, Horvath Z, Hochtl T, Steinbrugger R, Jager W, Krupitza G, Elford HL, Szekeres T. Trimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-C in HL-60 human promyelocytic leukemia cells. Biochem Pharmacol. 1;64(3):481-5. (2002)  

  • Hagenauer B, Maier-Salamon A, Thalhammer T, Zollner P, Senderowicz A, Jager W. Metabolism of UCN-01 in isolated perfused rat liver: role of Mrp2 in the biliary excretion of glucuronides. Oncol Rep.;11(5):1069-75. (2004).

  • Thalhammer F, Maier-Salamon A, Jäger W. Prüfung von Stabilität und Kompatibilität von Flucloxacillin (Floxapen®) und Ceftazidim (Fortum®) in zwei verschiedenen Infusionslösungen für den klinischen Alltag. Wiener klinische Wochenschrift 155 (13-14): 337-343 (2005).  

  • Miksits M, Maier-Salamon A, Aust S, Thalhammer T, Reznicek G, Kunert O, Haslinger E, Szekeres T, Jaeger W. Sulfation of resveratrol in human liver: evidence of a major role for the sulfotransferases SULT1A1 and SULT1E1. Xenobiotica. 35(12):1101-19. (2005).  

  • Maier-Salamon A, Hagenauer B, Wirth M, Gabor F, Szekeres T, Jäger W. Increased transport of resveratrol across monolayers of the human intestinal Caco-2 cells is mediated by inhibition and saturation of metabolites. Pharm Res. 23(9):2107-15. (2006)  

  • Maier-Salamon A, Hagenauer B, Reznicek G, Szekeres T, Thalhammer T, Jäger W. Metabolism and disposition of resveratrol in the isolated perfused rat liver: role of Mrp2 in the biliary excretion of glucuronides. J Pharm Sci. 97(4):1615-28 (2008).  

  • Maier-Salamon A, Trauner G, Hiltscher R, Reznicek G, Kopp B, Thalhammer T, Jäger W. Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: role of Mrp2 (Abcc2). J Pharm Sci.98(10):3839-49 (2009).  

  • Miksits M, Maier-Salamon A, Vo N, Sulyok M, Schuhmacher R, SzekeresT, Jäger W. Glucuronidation of piceatannol by human liver microsomes: major role of UGT1A1, UGT1A8 and UGT1A10. J. Pharm. Pharmacol. 62: 47–54. (2010)  

  • Maier-Salamon A, Böhmdorfer M, Thalhammer T, Szekeres T, Jaeger W. Hepatic glucuronidation of resveratrol: interspecies comparison of enzyme kinetic profiles in human, mouse, rat, and dog. Drug Metab Pharmacokinet.; 26: 364-73 (2011).

  • Böhmdorfer M, Maier-Salamon A, Taferner B, Reznicek G, Thalhammer T, Hering S, Hüfner A, Schühly W, Jäger W. In vitro metabolism and disposition of honokiol in rat and human livers. J Pharm Sci;100: 3506-16 (2011).  
  • Maier-Salamon A, Böhmdorfer M, Riha J, Thalhammer T, Szekeres T, Jaeger W. Interplay between metabolism and transport of resveratrol. Ann N Y Acad Sci. 1290:98-106. (2013)

  • Maier-Salamon A, Thalhammer T, Reznicek G, Böhmdorfer M, Zupkó I, Hartl A, Jaeger W. Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. Int J Oncol. 245(2):877-86. (2014)

  • Kisková T, Jendželovský R, Rentsen E, Maier-Salamon A, Kokošová N, Papčová Z, Mikeš J, Orendáš P, Bojková B, Kubatka P, Svoboda M, Kajo K, Fedoročko P, Jäger W, Ekmekcioglu C, Kassayová M, Thalhammer T. Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. Eur J Cancer Prev.; 23(6): 506-13. (2014)

  • Böhmdorfer M, Maier-Salamon A, Riha J, Brenner S, Höferl M, Jäger W. Interplay of drug metabolizing enzymes with cellular transporters. Wien Med Wochenschr. (2014)

Conference contributions

  • Salamon A., Sartori M, Halper B, Jaeger W, Boltz-Nitulescu G, Thalhammer T: In vitro metabolism of genistein in liver microsomes of control and mutant TR--rats. Experimental Biology 96, Washington, D.C., 14.4.-17.4. 1996, FASEB J. 10, A176 (1996).  

  • Halper B, Salamon A, Jaeger W, Boltz-Nitulescu G, Thalhammer T: Biliary excretion of genistein metabolites in control and mutant TR--rats. Experimental  Biology 96, Washington, D.C., 14.4.-17.4., FASEB J. 10, A178 (1996)  

  • Salamon A, Halper B, Szekeres T, Fritzer-Szekeres M, Thalhammer T, Jäger W: In vitro glucuronidation of Resveratrol by human microsomes. 14th Annual AAPS Meeting, New Orleans (14.11-18.11. 1999)  

  • Salamon A, Hagenauer B, Haslmayr P, Szekeres T, Fritzer-Szekeres M, Thalhammer T, Jäger W: Biotransformation of resveratrol by UDP glucuronosyl-transferase (UGT) isoenzymes  1A1 and 1A9 in human liver. 5. Jahrestagung d öster. Gesell. f Endokrinologie und Stoffwechsel, St. Wolfgang (27.04-29.04 2000)  

  • Salamon A, Halper B, Haslmayer P, Szekeres T, Fritzer-Szekeres M, Thalhammer T and Jäger W: Biotransformation of the Polyphenol Resveratrol in Human Liver. „Wissenschaftliche Wintertagung der Gesellschaft der Ärzte“, Wien (12.01 2000)  

  • Barich T, Thalhammer T, Jäger W, Hagenauer B, Salamon A, Alihodzic B, Bakos S, Hitchman E and Penner E: Characterization of autoantibodies directed against uridinediphophate-glucuronosyltransferase in patients with inflammatory liver diseases. Wissenschaftliche Wintertagung der Gesellschaft der Ärzte“, Wien (12.01 2000)  

  • Haslmayer P, Thalhammer T, Salamon A, Jäger W, Steiner G, Enzinger C, Obrist P: Regulation of peroxisome proliferator-activated receptor γ(PPARγ) expression by PG-J2 in human bladder and prostate carcinoma cell lines: determination by real time PCR. NEW ANTICANCER AGENTS ,Athen, Greece 09. 06. – 12. 06. 2001)  

  • Miksits M, Maier-Salamon A, Aust S, Thalhammer T, Szekeres T, Jaeger W. Sulfation of resveratrol a polyphenolic compound found in grapes and wine, in human liver. 19. Wissenschafttliche Tagung der Österreichischen Pharmazeutischen Gesellschaft, Innsbruck, Scientia pharmaceutica 74(2): 17 (2006).  

  • Miksits M, Maier-Salamon A, Aust S, Thalhammer T, Szekeres T, Jaeger W. Sulfation of resveratrol in human liver: evidence of a major role for the sulfotransferases SULT1A1 and SULT1E1. Drug Metabolism Reviews 39(1), A157 (2007).  

  • Vo N, Miksits M, Maier-Salamon A, Szekeres T, Jäger W. Metabolism of piceatannol in human liver microsomes: major role of UGT1A1, UGT1A8 and UGT1A10. Drug Metabolism Reviews 39(1), A263 (2007).

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