Kopp Lab

Molecular functions of mammalian noncoding RNAs and their roles in normal physiology and disease

Research Focus

Most of the human genome is transcribed into RNA, whereas only less than 2% encode protein coding exons. Among this vast non-protein-coding transcriptome is a heterogenous class of RNA referred to as long noncoding RNA (lncRNA) that has attracted increasing attention in biomedical research. While the number of annotated lncRNA genes has been steadily growing, the biological functions of most of these transcripts remain unknown.

Our laboratory uses modern molecular biology techniques and suitable genetic cell line and mouse models to study the human non-protein-coding genome and its role in normal physiology and disease. We seek to identify novel human noncoding RNAs, characterize their molecular functions and physiologic roles in various aspects of human biology, and explore their potential therapeutic applications as novel drug targets or biomarkers.