Mag.pharm. Dr. Stefan Poschner

Contact

Mail: stefan.poschner @ univie.ac.at

Phone: +43-1-4277-55543

Fax: +43-1-4277-855543

Room: 2E252

Sprechstunde: nach vorheriger Vereinbarung (via e-Mail)

Courses

Research interests

steroid metabolism in gynecological cancers (breast, ovary)
interaction of dietary supplements with endogenous metabolic processes
development and validation of HPLC-DAD, HPLC-HRMS and UPLC-HRMS methods for the identification and quantification of natural or pharmaceutical compounds
quantification of pharmaceutical drugs in biological matrices (plasma, bile, CSF, microdialysate,...)

Publications

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Journal Articles - 2024

St. John's wort extract with a high hyperforin content does not induce P-glycoprotein activity at the human blood-brain barrier

El Biali M, Wölfl-Duchek M, Jackwerth M, Mairinger S, Weber M, Bamminger K, Poschner S, Rausch I, Schindler N, Lozano IH, Jäger W, Nics L, Tournier N, Hacker M, Zeitlinger M, Bauer M, Langer O. Clin Transl Sci. 2024 May;17(5):e13804.
Journal Articles - 2023

Pilot Pharmacokinetic Study in Healthy Adults Using Intravascular Microdialysis Catheters Modified for Use in Paediatric Patients to Assess Vancomycin Blood Levels

Al Jalali V, Bauer M, Wölfl-Duchek M, Sarhan M, Wicha SG, Poschner S, Jäger W, König F, Male C, Zeitlinger M, Clin Pharmacokinet. 2023 Jan;62(1):77-87.
Journal Articles - 2022

Meropenem Population Pharmacokinetics and Simulations in Plasma, Cerebrospinal Fluid, and Brain Tissue

Alshaer MH, Barlow B, Maranchick N, Moser M, Gramss L, Burgmann H, Jalali VA, Wölfl-Duchek M, Jäger W, Poschner S, Plöchl W, Reinprecht A, Rössler K, Gruber A, Zeitlinger M, Peloquin CA, Hosmann A, Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0043822.

Pharmacokinetics of metronomic temozolomide in cerebrospinal fluid of children with malignant central nervous system tumors

Büsker S, Jäger W, Poschner S, Mayr L, Al Jalali V, Gojo J, Azizi AA, Ullah S, Bilal M, El Tabei L, Fuhr U, Peyrl A, Cancer Chemother Pharmacol. 2022 May;89(5):617-627.
Journal Articles - 2021

In the Model Cell Lines of Moderately and Poorly Differentiated Endometrial Carcinoma, Estrogens Can Be Formed via the Sulfatase Pathway

Pavlič R, Gjorgoska M, Hafner E, Sinreih M, Gajser K, Poschner S, Jäger W, Rižner TL, Front Mol Biosci. 2021 Nov 5;8:743403.

Meropenem concentrations in brain tissue of neurointensive care patients exceed CSF levels

Hosmann A, Ritscher L, Burgmann H, Al Jalali V, Wulkersdorfer B, Wölfl-Duchek M, Sanz Codina M, Jäger W, Poschner S, Plöchl W, Reinprecht A, Rössler K, Gruber A, Zeitlinger M, J Antimicrob Chemother. 2021 Aug 15:dkab286.

Altered Profile of E1-S Transporters in Endometrial Cancer: Lower Protein Levels of ABCG2 and OSTβ and Up-Regulation of SLCO1B3 Expression

Pavlič R, Vidic S, Anko M, Knific T, Büdefeld T, Marton K, Sinreih M, Poschner S, Jäger W, Frković-Grazio S, Rižner TL, Int J Mol Sci. 2021 Apr 7;22(8):3819.
Journal Articles - 2020

Actaea racemosa L. extract inhibits steroid sulfation in human breast cancer cells: Effects on androgen formation

Poschner S, Wackerlig J, Dobusch D, Pachmann B, Banh SJ, Thalhammer T, Jäger W, Phytomedicine. 2020 Sep 25;79:153357.

Metabolite profiling of natural substances in human: In vitro study from fecal bacteria to colon carcinoma cells (Caco-2)

Racova Z, Anzenbacherova E, Papouskova B, Poschner S, Kucova P, Gausterer JC, Gabor F, Kolar M, Anzenbacher P, J Nutr Biochem. 2020 Aug 12;85:108482.

Metabolism of Estrogens: Turnover Differs Between Platinum-Sensitive and -Resistant High-Grade Serous Ovarian Cancer Cells

Poschner S, Wackerlig J, Castillo-Tong DC, Wolf A, Decken IV, Rižner TL, Pavlič R, Meshcheryakova A, Mechtcheriakova D, Fritzer-Szekeres M, Thalhammer T, Jäger W, Cancers (Basel). 2020 Jan 23;12(2). pii: E279.

Impact of thrombocytes, on bacterial growth and antimicrobial activity of selected antibiotics

Nussbaumer-Pröll AK, Eberl S, Reiter B, Stimpfl T, Jäger W, Poschner S, Zeitlinger M, Eur J Clin Microbiol Infect Dis. 2020 Mar;39(3):593-597.
Journal Articles - 2019

Resveratrol and other dietary polyphenols are inhibitors of estrogen metabolism in human breast cancer cells

Poschner S, Maier-Salamon A, Thalhammer T, Jäger W, J Steroid Biochem Mol Biol. 2019 Mar 6;190:11-18.

Impact of erythrocytes on bacterial growth and antimicrobial activity of selected antibiotics

Nussbaumer-Pröll AK, Knotzer S, Eberl S, Reiter B, Stimpfl T, Jäger W, Poschner S, Zeitlinger M, Eur J Clin Microbiol Infect Dis. 2019 Mar;38(3):485-495.

Inhibition of ABCB1 and ABCG2 at the Mouse Blood-Brain Barrier with Marketed Drugs To Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [(11)C]erlotinib

Traxl A, Mairinger S, Filip T, Sauberer M, Stanek J, Poschner S, Jäger W, Zoufal V, Novarino G, Tournier N, Bauer M, Wanek T, Langer O, Mol Pharm. 2019 Mar 4;16(3):1282-1293.
Journal Articles - 2018

A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier

Bauer M, Karch R, Wulkersdorfer B, Philippe C, Nics L, Klebermass EM, Weber M, Poschner S, Haslacher H, Jäger W, Tournier N, Wadsak W, Hacker M, Zeitlinger M, Langer O, J Nucl Med. 2018 Sep 20. pii: jnumed.118.216432.

Effect of Rifampicin on the Distribution of [(11)C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

Bauer M, Traxl A, Matsuda A, Karch R, Philippe C, Nics L, Klebermass EM, Wulkersdorfer B, Weber M, Poschner S, Tournier N, Jäger W, Wadsak W, Hacker M, Wanek T, Zeitlinger M, Langer O, Mol Pharm. 2018 Oct 1;15(10):4589-4598.

Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation

Poschner S, Maier-Salamon A, Zehl M, Wackerlig J, Dobusch D, Meshcheryakova A, Mechtcheriakova D, Thalhammer T, Pachmann B, Jäger W, Front Pharmacol. 2018 Jul 10;9:742.

Concentrations of Cefuroxime in Brain Tissue of Neurointensive Care Patients

Hosmann A, Ritscher LC, Burgmann H, Oesterreicher Z, Jäger W, Poschner S, Knosp E, Reinprecht A, Gruber A, Zeitlinger M, Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02164-17.

The Impacts of Genistein and Daidzein on Estrogen Conjugations in Human Breast Cancer Cells: A Targeted Metabolomics Approach

Poschner S, Maier-Salamon A, Zehl M, Wackerlig J, Dobusch D, Pachmann B, Sterlini KL, Jäger W, Front Pharmacol. 2017 Oct 5;8:699.

Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography

Bauer M, Matsuda A, Wulkersdorfer B, Philippe C, Traxl A, Özvegy-Laczka C, Stanek J, Nics L, Klebermass EM, Poschner S, Jäger W, Patik I, Bakos É, Szakács G, Wadsak W, Hacker M, Zeitlinger M, Langer O, Clin Pharmacol Ther. 2018 Jul;104(1):139-147.
Journal Articles - 2017

Human Bile Reduces Antimicrobial Activity of Selected Antibiotics against Enterococcus faecalis and Escherichia coli In Vitro

Wulkersdorfer B, Jaros D, Eberl S, Poschner S, Jäger W, Cosentini E, Zeitlinger M, Schwameis R, Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00527-17.

Simultaneous quantification of estrogens, their precursors and conjugated metabolites in human breast cancer cells by LC-HRMS without derivatization

Poschner S, Zehl M, Maier-Salamon A, Jäger W, J Pharm Biomed Anal. 2017 May 10;138:344-350.
Conference Contributions

Pharmacokinetics of temozolomide in cerebrospinal fluid of children with malignant tumors - a pilot study

Büsker S, Peyrl A, Al Jaliali V, Jäger W, Poschner S, Ullah S, El Tabei L, Fuhr U, 15th Congress of the European Association for Clinical Pharmacology and Therapeutics, postponed to June 2022 (?), Athens, Greece.

Higher meropenem concentrations in brain tissue compared to cerebrospinal fluid in neurointensive care patients

Sanz Codina M, Hosmann A, Ritscher L, Burgmann H, Al Jalali V, Wulkersdorfer B, Wölfl-Duchek M, Jäger W, Poschner S, Plöchl W, Reinprecht A, Rössler K, Gruber A, Zeitlinger M, poster presentation, 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), July 2021, Online.

Development of intravascular microdialysis as a tool for therapeutic drug monitoring and intensive PK studies in children

Al Jalali V, Wulkersdorfer B, Matzneller P, Lackner E, Poschner S, Jaeger W, Zeitlinger M, poster presentation, 30th European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), April 2020, Paris, France.

Black cohosh impairs steroid metabolism in human breast cancer cells: a targeted metabolomics approach

Poschner S, Maier-Salamon A, Wackerlig J, Dobusch D, Pachmann B, Banh SJ, Jäger W, oral presentation, 17th Austrian Proteomics and Metabolomics Research Symposium, September 2019, Salzburg, Austria.

Targeted metabolomics of steroids by LC-HRMS: application to platinum-sensitive and -resistant human ovarian cancer cells

Poschner S, Zehl M, Wackerlig J, Dobusch D, Castillo-Tong DC, Wolf A, Thalhammer T, Jäger W, oral presentation, 16th Austrian Proteomics and Metabolomics Research Symposium, August 2018, Vienna, Austria.

Resveratrol inhibits key steps of steroid metabolism in a human estrogen-receptor positive breast cancer model: impact on cellular Proliferation

Poschner S, Maier-Salamon A, Zehl M, Wackerlig J, Dobusch D, Pachmann B, Jäger W, oral presentation, 4th Congress on Steroid Research, July 2018, Seoul, South Korea.