Molecular functions of mammalian noncoding RNAs and their roles in normal physiology and disease

Our Mission

Clinical Pharmacy comprises a broad spectrum of research disciplines that all aim to improve the efficacy and safety of patient therapies. Understanding the genetic basis of human diseases and related pharmacotherapies is key to improve existing therapies and develop new innovative therapeutic interventions. The identification of new molecular drug targets, biomarkers as well as drug-specific metabolism and cellular transport are critical for the discovery and development of novel patient-tailored therapies.

In our group, we focus on the noncoding transcriptome and explore new molecular functions of noncoding RNAs and their roles in normal physiology and disease as well as their therapeutic implications.

We use modern molecular biology and analytical techniques together with suitable cell-based, animal and human model systems to study the noncoding transcriptome and its role in human diseases and pharmacotherapy. We seek to identify novel human noncoding RNAs, characterize their molecular and physiological functions and explore their potential therapeutic applications as novel drug targets or biomarkers. Using sensitive analytical methods, we also seek to identify the role of noncoding RNAs in the metabolism and cellular transport of drugs, natural compounds and endogenous metabolites. With this comprehensive approach we hope to discover and develop novel RNA-based precision therapies for human diseases with a high unmet medical need.