Our Research Mission

In our group, we focus on the noncoding transcriptome and explore new molecular functions of noncoding RNAs and their roles in normal physiology and disease, with particular emphasis on stress responses, tissue homeostasis, regeneration, and aging and aging-related diseases, as well as their therapeutic implications.

We use modern molecular biology and analytical techniques together with suitable cell-based, animal, and human model systems to study the noncoding transcriptome and its role in human diseases and pharmacotherapy. We seek to identify novel human noncoding RNAs, characterize their molecular and physiological functions in processes such as cellular stress adaptation and tissue maintenance, and explore their potential therapeutic applications as novel drug targets or biomarkers. With this comprehensive approach, we aim to discover and develop innovative RNA-based precision therapies for human diseases with a high unmet medical need.

Moreover, our research group focuses on pharmacogenetics, developing and refining testing strategies to guide individualized drug therapy. We investigate key biological pathways that influence drug response and adverse effects, including the regulatory roles of the noncoding genome as well as protein-coding genes and canonical signaling pathways. By integrating genomic, transcriptomic, and clinical data, we aim to advance implementation strategies that translate pharmacogenetic insights into routine clinical care.